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Updated: Aug 6, 2026

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
Published on: November 3, 2018
Rheumatic manifestations in patients with myelodysplastic and myeloproliferative diseases
P V Kuzmich1, G A Ecker, J Karsh
1Division of Rheumatology, Ottawa General Hospital, University of Ottawa, ON, Canada.
Objective:
To evaluate the rheumatic complications in patients with myelodysplastic and myeloproliferative diseases.
Methods:
A retrospective chart review of patients with a rheumatic disease and either a myelodysplastic or myeloproliferative disorder diagnosed on bone marrow examination.
Results:
Nine patients were identified, 5 with myelodysplastic and 4 with myeloproliferative disorders. Polyarthritis was the most common rheumatic presentation, occurring in 6 patients with a positive rheumatoid factor in 4. Necrotizing vasculitis complicated the course in 3 patients. Autoantibodies and hypergammaglobulinemia were present in the majority of patients.
Conclusion:
There is an association between hematologic disorders caused by proliferation of bone marrow derived pluripotent stem cells and rheumatic disorders.
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