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Arthritis in a patient with psoriasis after interferon-alpha therapy for chronic hepatitis C
Y Makino1, H Tanaka, K Nakamura
1Second Department of Internal Medicine, Asahikawa Medical College, Japan.
The Journal of Rheumatology
|September 1, 1994
Abstract:
A 27-year-old man with psoriasis was administered with leukocyte derived interferon-alpha for the treatment of chronic persistent hepatitis C. After 3 weeks of injections and eventual normalization of serum levels of alanine aminotransferase, he began to experience polyarthritis, with worsening of psoriatic skin lesions. Tests for antinuclear antibodies and rheumatoid factor were negative, indicating a direct association between interferon therapy and occurrence of seronegative arthritis.