[Simplified determination of proteinuria in children using a single urine sample]

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Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

E Bisaz1, M G Bianchetti, R Donati

  • 1Abteilung für Nephrologie, Universität, Inselspital, Bern, Schweiz.

Klinische Padiatrie
|September 1, 1994
PubMed

Insights

The random urine protein/creatinine ratio accurately assesses protein excretion in pediatric patients, simplifying diagnosis by eliminating the need for timed urine collections in evaluating kidney disease.

Area of Science:

  • Pediatric Nephrology
  • Clinical Chemistry

Context:

  • Evaluating proteinuria in children and adolescents typically requires cumbersome timed urine collections.
  • Accurate quantitative assessment of protein excretion is crucial for diagnosing and monitoring renal disease in pediatric populations.

Purpose:

  • To evaluate the accuracy of the random urine protein/creatinine ratio as a substitute for timed urine collections in pediatric patients with renal disease.
  • To establish reference ranges for the urine protein/creatinine ratio in healthy children and adolescents.

Summary:

  • A study involving 134 pediatric patients with renal disease and 252 healthy children demonstrated a close correlation between the random urine protein/creatinine ratio and overnight urine protein excretion rates.
  • The upper limit of the urine protein/creatinine ratio in healthy individuals was determined to be 19 mg/mmol, with no significant age-related differences observed.
  • The protein/creatinine ratio, measured using Coomassie blue binding and kinetic Jaffe reaction methods, proved to be an accurate and practical method for assessing proteinuria.

Impact:

  • The random urine protein/creatinine ratio offers a simpler, more accurate, and less burdensome method for evaluating proteinuria in pediatric patients.
  • This method can reduce diagnostic errors and improve the efficiency of managing kidney disease in children and adolescents.

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