[Local preventive antibacterial therapy with polymer biocompatible combination]

Area of Science:

• Surgical Infection Prevention
• Antimicrobial Therapeutics
• Wound Healing Research

Background:

• Postoperative wound infections pose a significant challenge in surgical outcomes.
• Conventional antibacterial therapies have limitations in achieving sustained local concentrations.
• Novel drug delivery systems are needed for effective topical antimicrobial treatment.

Purpose of the Study:

• To evaluate the efficacy of Ambipor, a powdery antimicrobial absorbent, in preventing postoperative suppuration.
• To assess the pharmacokinetic profile and impact of Ambipor on wound healing processes.
• To determine the reduction in microbial dissemination and complication rates following Ambipor application.

Main Methods:

• Data collection on Ambipor properties and its application procedure before wound closure.
• Measurement of paravulnar tissue antibiotic concentrations after single Ambipor application.
• Quantification of microbial dissemination reduction and assessment of reparative processes (fibroblast activation, fibrillogenesis, scarring).

Main Results:

• Single Ambipor application achieved high paravulnar tissue antibiotic concentrations, exceeding conventional therapy levels.
• Ambipor reduced microbial dissemination by 100-1000 times.
• Accelerated reparative processes, including fibroblast activation and scar maturation, were observed.
• A significant decrease in postoperative complication incidence (over 4.5 times) compared to controls.

Conclusions:

• Topical antibacterial therapy with Ambipor is an effective strategy for preventing postoperative wound complications.
• Ambipor ensures high local antibiotic concentrations and promotes faster wound healing.
• Clinical application of Ambipor can substantially decrease the incidence of surgical site infections.