Sixth Annual Stuart Reiner Memorial Lecture: embryonic development of nerve and muscle

This article provides a basic scheme of sequential anatomic and some physiologic events occurring during the course of embryonic development of motor neurons and muscles, leading to the establishment of mature nerve-muscle relationships. Motor neurons and muscles begin their development independently and during embryogenesis they become dependent on each other for further development and survival. Aspects of development which occur independently and those requiring mutual interactions are identified. The development of motor neurons is discussed with respect to their production, projection, neuromuscular transmission, myelination, sprouting, survival, and death. The development of muscles is discussed with respect to the origin, differentiation, and muscle fiber types. Discussion on the development of neuromuscular junction includes differentiation of presynaptic nerve terminal, postsynaptic components, and elimination of multiple axons.