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[Vitamin E, antioxidants and atherosclerosis]

J M Lecerf1, G Luc, J C Fruchart

  • 1Centre clinico-biologique des lipides, CHRU, hôpital Claude-Huriez, Lille, France.

La Revue De Medecine Interne
|January 1, 1994
PubMed
Summary

Oxidized low-density lipoprotein (LDL) contributes to atherosclerosis development. Dietary antioxidants may play a role in preventing and treating this condition, with ongoing research into LDL oxidation susceptibility.

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Area of Science:

  • Biochemistry
  • Cardiovascular Science

Context:

  • Atherosclerosis involves lipid accumulation and oxidation.
  • Oxidized LDL triggers foam cell formation, initiating fatty streaks.
  • Foam cells exhibit cytotoxic and chemotactic properties, advancing atherogenesis.

Purpose:

  • To review mechanisms of antioxidant protection against lipid oxidation.
  • To examine epidemiological, experimental, and clinical data on antioxidants in atherosclerosis.
  • To highlight the need for considering dietary factors in atherosclerosis prevention and therapy.

Summary:

  • Atherosclerosis pathogenesis involves oxidized low-density lipoprotein (LDL) and macrophage pathways, leading to foam cell formation and early lesions.
  • Natural dietary antioxidants and vitamins offer protection against free radicals and oxidation.
  • Current data suggest the importance of antioxidants in managing atherosclerosis and dyslipidemia, with ongoing research into LDL oxidation susceptibility.

Impact:

  • Emphasizes the potential role of dietary antioxidants in managing atherosclerosis and dyslipidemia.
  • Underscores the need for further research, particularly intervention surveys, to confirm the efficacy of nutritional and medical treatments.
  • Provides a foundation for future studies investigating the link between LDL oxidation and cardiovascular health.

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