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Related Experiment Videos

Abnormal colonic microbial function in patients with rheumatoid arthritis

P Benno1, M Alam, K Henriksson

  • 1Department of Internal Medicine, Danderyd Hospital, Sweden.

Scandinavian Journal of Rheumatology
|January 1, 1994
PubMed
Summary

Rheumatoid arthritis patients show abnormal cholesterol conversion in their gut microflora. Sulphasalazine treatment impacts these gut bacteria functions, altering fecal tryptic activity and urobilinogen levels.

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) is associated with gut microflora alterations.
  • Microflora-associated characteristics (MACs) may be affected in RA patients.

Purpose of the Study:

  • To investigate MACs in RA patients.
  • To evaluate the effect of sulphasalazine (SASP) on RA patient MACs.

Main Methods:

  • Measured cholesterol to coprostanol conversion, urobilinogen production, and fecal tryptic activity (FTA).
  • Analyzed fecal samples from 19 RA patients on SASP, 21 RA patients not on SASP, and 21 healthy controls.

Main Results:

  • High cholesterol converters were more frequent in untreated RA patients than in controls (p < 0.05).

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  • SASP treatment significantly increased FTA and decreased urobilinogen compared to untreated RA patients (p < 0.05).
  • Beta-aspartylglycine was not detected.

    • Conclusions:

    • RA patients exhibit abnormal coprostanol formation, suggesting Eubacteria dysfunction.
    • SASP treatment alters gut microflora metabolism in RA patients.