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[Voluntary poisoning with dexfenfluramine (Isomeride)]

D Genné1, A De Torrenté, L Humair

  • 1Service de médecine interne, Hôpital de la ville, La Chaux-de-Fonds.

Schweizerische Medizinische Wochenschrift
|December 10, 1994
PubMed
Summary

Dexfenfluramine, an appetite suppressant, can cause acute intoxication with symptoms like rapid heart rate and fever. These effects, similar to amphetamine overdose, resolved within 48 hours in a young patient.

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Area of Science:

  • Pharmacology
  • Toxicology
  • Clinical Medicine

Background:

  • Dexfenfluramine is a widely prescribed appetite suppressant in Switzerland, often used to aid weight-reducing diets.
  • The effects of acute dexfenfluramine intoxication are not well-documented in medical literature.
  • Adolescent use of appetite suppressants for rapid weight loss is a growing concern.

Observation:

  • A case study involved a young adolescent female who ingested a large quantity of dexfenfluramine for rapid weight loss.
  • The patient presented with symptoms including tachycardia, hypertension, mydriasis, fever, and behavioral disturbances.
  • These acute intoxication symptoms are clinically similar to those observed in amphetamine overdose.

Findings:

  • The adolescent patient's symptoms, including tachycardia, hypertension, mydriasis, fever, and behavioral changes, were consistent with acute dexfenfluramine intoxication.
  • All observed signs and symptoms resolved completely within a 48-hour period without specific intervention.
  • The clinical presentation strongly resembles amphetamine intoxication due to shared metabolic pathways or active metabolites.

Implications:

  • This case highlights the potential dangers of acute dexfenfluramine overdose, particularly in adolescents seeking rapid weight loss.
  • The similarity to amphetamine intoxication suggests a need for careful differential diagnosis in cases of suspected stimulant overdose.
  • Further research into the toxicological profile and management of dexfenfluramine overdose is warranted.

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