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Silicone toxicology

H Busch1

  • 1Baylor College of Medicine, Houston, TX 77030.

Seminars in Arthritis and Rheumatism
|August 1, 1994
PubMed
Summary
This summary is machine-generated.

Silicone from breast implants is not biologically inert and can cause adverse reactions. This man-made polymer and its contaminants may lead to inflammation, fibrosis, and potential toxicity in recipients.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Medical Device Technology

Background:

  • Silicone, a silicon-based polymer, is widely used in medical devices, notably breast implants.
  • It was historically considered biologically inert, meaning it wouldn't interfere with physiological processes.

Purpose of the Study:

  • To investigate the biological inertness of silicone used in breast implants.
  • To identify the reactions and potential toxicity associated with silicone in medical devices.

Main Methods:

  • Analysis of silicone's interaction with surrounding tissues in breast implant recipients.
  • Identification of silicone and contaminant migration and associated biological responses.

Main Results:

Related Experiment Videos

  • Silicone from breast implants is not inert; it "bleeds" through the implant envelope.
  • Silicone and its contaminants trigger foreign body reactions, including granulomatous inflammation and fibrosis.
  • Evidence suggests potential for significant toxicity in implant recipients.

    • Conclusions:

    • Silicone's purported biological inertness is inaccurate.
    • Silicone and associated contaminants pose risks of inflammation, fibrosis, and toxicity.
    • Further research is needed to understand the full toxicological profile of silicone in medical implants.