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Vascular mineralization in the monkey brain

T Yanai1, T Masegi, K Ueda

  • 1Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan.

Veterinary Pathology
|September 1, 1994
PubMed
Summary
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Brain mineralization, a common finding in cynomolgus monkeys, affects vascular walls without impacting health. This study details the types and composition of these mineral deposits.

Area of Science:

  • Neuroscience
  • Primate Pathology
  • Mineral Metabolism

Background:

  • Mineralization in primate brains is not fully understood.
  • Cynomolgus monkeys (Macaca fascicularis) are relevant models for studying neurological conditions.

Purpose of the Study:

  • To characterize the incidence, morphology, and composition of brain mineralization in cynomolgus monkeys.
  • To investigate potential correlations with age, sex, and health parameters.

Main Methods:

  • Histopathological examination using periodic acid-Schiff and von Kossa stains.
  • Electron microscopy for ultrastructural analysis.
  • X-ray microanalysis for elemental composition.

Main Results:

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  • Mineralization observed in 59% of 134 monkeys, primarily in globus pallidus vascular walls.
  • Two distinct types of mineralization (globoid bodies and fine granules) were identified.
  • Deposits contained calcium, phosphorus, iron, zinc, magnesium, and aluminum.

    • Conclusions:

    • Brain mineralization is prevalent in cynomolgus monkeys and occurs in specific vascular patterns.
    • The observed mineralization does not appear to affect growth, weight, or neurological function.
    • Elemental analysis reveals a complex composition of these mineral deposits.