Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Atypical depression: clinical aspects and noradrenergic function

G M Asnis1, L K McGinn, W C Sanderson

  • 1Department of Psychiatry, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10467.

The American Journal of Psychiatry
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing the nature of grief and growth in bereaved, divorced, and unemployed individuals.

Journal of affective disorders·2020
Same author

Comment on 5-HT and mechanisms of defence.

Journal of psychopharmacology (Oxford, England)·2012
Same author

HIV and HCV health beliefs in an inner-city community.

Journal of viral hepatitis·2010
Same author

Paroxetine for prevention of depressive symptoms induced by interferon-alpha and ribavirin for hepatitis C.

Alimentary pharmacology & therapeutics·2007
Same author

New onset of body dysmorphic disorder following frontotemporal lesion.

Neurology·2003
Same author

Mean Beck Depression Inventory-II scores by severity of major depressive episode.

Psychological reports·2001

Atypical depression, characterized by mood reactivity and specific symptoms, affects 29% of depressed outpatients. This subtype may involve a less impaired norepinephrine system compared to nonatypical depression.

Area of Science:

  • Psychiatry and Behavioral Sciences
  • Neuroscience

Background:

  • Atypical depression is a specifier for depressive disorders.
  • Its prevalence and biological underpinnings require further investigation.

Purpose of the Study:

  • To determine the frequency of atypical depression in a cohort of depressed outpatients.
  • To compare the clinical and biological characteristics of patients with atypical versus nonatypical depression.

Main Methods:

  • 114 depressed outpatients were diagnosed using the Schedule for Affective Disorders and Schizophrenia (SADS).
  • Atypical depression was identified using the Atypical Depressive Disorder Scale, defined by mood reactivity plus specific associated features.
  • Cortisol response to desipramine was assessed to evaluate biological functioning.

Related Experiment Videos

Main Results:

  • 29% of patients met criteria for atypical depression; this group was more likely to be female.
  • No significant differences were found in SCL-90 scores between atypical and nonatypical depression groups.
  • Patients with atypical depression showed a distinct cortisol response to desipramine, suggesting a potentially less impaired norepinephrine system.

Conclusions:

  • Atypical depression presents a unique symptom profile and may be prevalent.
  • Findings suggest atypical depression might be associated with a less impaired biological system compared to nonatypical depression.
  • The data support considering atypical depression as a distinct subtype in diagnostic criteria (DSM-IV).