Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating fluoride changes and hepatorenal function following sevoflurane anaesthesia

P J Newman1, A C Quinn, G M Hall

  • 1Department of Anaesthesia, St George's Hospital Medical School, London.

Anaesthesia
|November 1, 1994
PubMed
Summary

Sevoflurane anesthesia produces higher serum fluoride levels than isoflurane, though neither agent caused kidney or liver dysfunction in patients undergoing major surgery. Fluoride levels correlated with sevoflurane dose.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pseudoaxioms in the intrapartum management of diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2019
Same author

Time to GRADE recommendations.

Diabetic medicine : a journal of the British Diabetic Association·2019
Same author

Hemizygosity for the gene encoding glycoprotein Ibβ is not responsible for macrothrombocytopenia and bleeding in patients with 22q11 deletion syndrome.

Journal of thrombosis and haemostasis : JTH·2018
Same author

National guidance contributes to the high incidence of inpatient hypoglycaemia.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

'Primum non nocere' (first do no harm). Intrapartum glycaemic control and neonatal hypoglycaemia.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

Effects of arterial load variations on dynamic arterial elastance: an experimental study.

British journal of anaesthesia·2017

Area of Science:

  • Anesthesiology
  • Nephrology
  • Pharmacology

Background:

  • Sevoflurane is a volatile anesthetic agent.
  • Biotransformation of sevoflurane yields fluoride, a substance with potential nephrotoxic effects.
  • Assessing the impact of sevoflurane on renal and hepatic function is crucial.

Purpose of the Study:

  • To compare the effects of sevoflurane and isoflurane anesthesia on hepatorenal function.
  • To measure and compare serum fluoride concentrations following sevoflurane and isoflurane anesthesia.
  • To investigate the correlation between anesthetic agent dose and fluoride production.

Main Methods:

  • A comparative study involving 50 patients (ASA 1-3) undergoing major intra-abdominal surgery.
  • Administration of either sevoflurane or isoflurane anesthesia.

Related Experiment Videos

  • Monitoring of hepatorenal function and measurement of serum fluoride concentrations.

    • Main Results:

    • No instances of renal or hepatic dysfunction were observed in any patient.
    • Mean peak serum fluoride concentrations were significantly higher with sevoflurane (23.1 mumol.l-1) compared to isoflurane (5.4 mumol.l-1) (p < 0.001).
    • In the sevoflurane group, a significant correlation was found between the anesthetic dose (MAC h) and both total fluoride production (r = 0.78) and peak fluoride concentration (r = 0.57).

    Conclusions:

    • Neither sevoflurane nor isoflurane anesthesia led to hepatorenal dysfunction in the study population.
    • Sevoflurane anesthesia results in significantly higher serum fluoride concentrations compared to isoflurane.
    • The dose of sevoflurane administered directly correlates with the resulting fluoride levels, highlighting a dose-dependent relationship.