Occurrence of primary renal angiosarcoma in brothers

Two brothers, 3 years apart in age, developed angiosarcoma of the left kidney at ages 52 and 69. Both rapidly developed systemic metastasis and died 6 weeks and 3 months, respectively, after nephrectomy. No common carcinogen or hereditary or other etiologic factor was identified. To our knowledge these two cases bring the total of reported cases of renal angiosarcoma to eight, with these representing the only ones with a familial occurrence.