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Creatine kinase elevations with clozapine

M S Keshavan1, J Stecker, R K Kambhampati

  • 1Schizophrenia Inpatient Unit, University of Pittsburgh, PA.

The British Journal of Psychiatry : the Journal of Mental Science
|January 1, 1994
PubMed
Summary

Clozapine treatment can cause significant creatine kinase elevations, a condition that resolves upon drug discontinuation. This adverse effect did not meet criteria for neuroleptic malignant syndrome.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Clinical Medicine

Background:

  • Clozapine is an atypical antipsychotic used for treatment-resistant schizophrenia.
  • Monitoring for adverse effects is crucial during clozapine therapy.

Observation:

  • A patient exhibited marked elevations in creatine kinase levels after initiating clozapine.
  • These enzyme elevations were observed without meeting the diagnostic criteria for neuroleptic malignant syndrome.

Findings:

  • Creatine kinase levels normalized rapidly after clozapine treatment was discontinued.
  • The findings suggest a potential link between clozapine and elevated creatine kinase.

Implications:

  • This case highlights a potential adverse drug reaction to clozapine that requires monitoring.

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  • Further investigation may be warranted to understand the mechanism of clozapine-induced creatine kinase elevation.