Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Hydroxyapatite for laryngotracheal framework reconstruction]

Y Ruan1, W Chen

  • 14th Military Medical University, Xi'an.

Zhonghua Er Bi Yan Hou Ke Za Zhi
|January 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Silent nucleotide substitution in the sterol 27-hydroxylase gene (CYP 27) leads to alternative pre-mRNA splicing by activating a cryptic 5' splice site at the mutant codon in cerebrotendinous xanthomatosis patients.

Biochemistry·1998
Same author

Comparison of structural stabilities of prostaglandin H synthase-1 and -2.

The Journal of biological chemistry·1998
Same author

The effect of age-dependent increase in fat mass on peripheral insulin action is saturable.

The journals of gerontology. Series A, Biological sciences and medical sciences·1998
Same author

Recurrence rates after the first course of isotretinoin.

Archives of dermatology·1998
Same author

Infected cell protein (ICP)47 enhances herpes simplex virus neurovirulence by blocking the CD8+ T cell response.

The Journal of experimental medicine·1998
Same author

Adhesion to fibronectin's EDb domain induces tyrosine phosphorylation of focal adhesion proteins in Balb/c 3T3 cells.

Clinical & experimental metastasis·1998
Same journal

[Culture of neural stem cells from rat olfactory bulb].

Zhonghua er bi yan hou ke za zhi·2005
Same journal

[Research of fibronectin, p53 and Ezrin protein with occurrence, progress and prognosis in the primary laryngeal carcinoma by the tissuechip technology].

Zhonghua er bi yan hou ke za zhi·2005
Same journal

[Effects of basic fibroblast growth factor on protein kinase B activity and c-fos expression in CNE- I nasopharyngeal carcinoma cell line].

Zhonghua er bi yan hou ke za zhi·2005
Same journal

[Nasal alar reconstruction with a vascularized free auricular composite flap].

Zhonghua er bi yan hou ke za zhi·2005
Same journal

[Effect of intranasal glucosteroid on the gene expression of interleukin-5 in nasal polyps].

Zhonghua er bi yan hou ke za zhi·2005
Same journal

[Roles of epidermal growth factor and its receptor on the chronic tympanic membrane perforations].

Zhonghua er bi yan hou ke za zhi·2005
See all related articles

This study combined sternohyoid myocutaneous flaps with hydroxyapatite (HA) grafts for laryngotracheal reconstruction. The procedure successfully restored airways in patients with severe stenosis, showing no implant rejection.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Surgical Innovation

Context:

  • Severe laryngotracheal stenosis presents significant challenges in airway management.
  • Current reconstructive techniques have limitations in long-term efficacy and biocompatibility.
  • The need for robust and biocompatible materials for airway reconstruction is critical.

Purpose:

  • To evaluate the efficacy of a combined sternohyoid myocutaneous flap and hydroxyapatite (HA) graft for laryngotracheal reconstruction.
  • To assess the biocompatibility and integration of HA implants in a clinical setting.
  • To determine the potential of this combined approach for treating severe laryngotracheal stenosis.

Summary:

  • A novel surgical technique involving sternohyoid myocutaneous flaps and custom-designed hydroxyapatite (HA) rings was utilized for laryngotracheal framework reconstruction in 10 patients.

Related Experiment Videos

  • Pre-clinical animal studies informed the clinical application of HA implants.
  • The HA implants demonstrated excellent integration and biocompatibility, with no instances of rejection or implant failure observed across all cases.

    • Impact:

    • Successful laryngotracheal reconstruction using HA grafts can significantly improve patient outcomes and quality of life.
    • This approach offers a promising alternative for managing complex airway defects where traditional methods are insufficient.
    • The study provides strong evidence for the clinical utility of HA biomaterials in complex reconstructive surgery.