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Chronic granulocytic leukaemia presenting with an extramedullary T lymphoblastic crisis
A Jacob1, D C Rowlands, N Patton
1Department of Haematology, Queen Elizabeth Hospital, Birmingham.
British Journal of Haematology
|October 1, 1994
Abstract:
A 33-year-old man presented with hepatosplenomegaly and lymphadenopathy. Bone marrow findings were consistent with Philadelphia-positive accelerated-phase chronic granulocytic leukaemia (CGL). Lymph node histology and immunhistochemistry were diagnostic of T lymphoblastic lymphoma. Molecular studies on lymph node DNA identified rearrangement within the major breakpoint cluster region (M-bcr), indicating a common clonal origin of CGL and the T lymphoblastic lymphoma. We report the second case where extramedullary T lymphoblastic crisis was the presenting feature of CGL.