Midazolam in emergency surgery--a pilot study on adult Nigerian patients

The effectiveness and safety of midazolam in induction of anaesthesia was studied in 15 ASA class II or III patients who required emergency surgery. In each case a slower and smoother transition at induction of anaesthesia was desired, as well as cardiovascular stability. All patients received 0.5 mg atropine and midazolam premedication (10-12.5 mg i.m) 20 to 30 minutes before induction. Anaesthesia was induced with 0.2 mg/kg of midazolam administered intravenously over 30 seconds. The induction time, degree of anterograde amnesia and incidence of local tolerance were evaluated. The pulse rate, blood pressure and ECG were monitored and recorded throughout the duration of surgery. The recovery time was also assessed. The mean induction time was 82.73 seconds and transition was smooth in all cases. Tolerability was good as well as the amnestic effect. Outcome was rated as very good in terms of cardiovascular stability and all the patients recovered rapidly.