Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium/calmodulin-dependent protein kinases

A C Nairn1, M R Picciotto

  • 1Rockefeller University, New York, NY 10021.

Seminars in Cancer Biology
|August 1, 1994
PubMed
Summary

Calcium (Ca2+) acts as a vital intracellular messenger, regulating key cellular functions. This review covers Ca2+-dependent protein kinases, which mediate Ca2+ effects through protein phosphorylation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dysregulated calcium signaling in the aged macaque entorhinal cortex associated with tau hyperphosphorylation.

bioRxiv : the preprint server for biology·2024
Same author

Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability.

Science advances·2021
Same author

Inhibition of STEP<sub>61</sub> ameliorates deficits in mouse and hiPSC-based schizophrenia models.

Molecular psychiatry·2016
Same author

Rare human nicotinic acetylcholine receptor α4 subunit (CHRNA4) variants affect expression and function of high-affinity nicotinic acetylcholine receptors.

The Journal of pharmacology and experimental therapeutics·2014
Same author

Reduced locomotor responses to cocaine in ghrelin-deficient mice.

Neuroscience·2011
Same author

Localization of dopamine- and cAMP-regulated phosphoprotein-32 and inhibitor-1 in area 9 of Macaca mulatta prefrontal cortex.

Neuroscience·2010

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Calcium ions (Ca2+) are critical intracellular second messengers in eukaryotes.
  • Ca2+ signaling pathways regulate essential cellular processes like muscle contraction, neurotransmitter release, gene expression, and cell proliferation.
  • Calmodulin (CaM) is a primary mediator of Ca2+ effects, often through protein phosphorylation.

Purpose of the Study:

  • To review the structure, regulation, and function of CaM-dependent protein kinases.
  • To highlight the role of these kinases in translating Ca2+ signals into cellular responses.

Main Methods:

  • Literature review of CaM-dependent protein kinases.
  • Analysis of the known structures, regulatory mechanisms, and biological functions of these enzymes.

Main Results:

  • Identification of a family of CaM-dependent protein kinases, including MLCK, PhK, CaMK I, CaMK II, EF-2K (CaMK III), and CaMK IV.
  • These kinases play a central role in mediating the diverse cellular effects of Ca2+/CaM.
  • Protein phosphorylation is a key mechanism by which CaM-dependent protein kinases exert their regulatory functions.

Conclusions:

  • CaM-dependent protein kinases are a crucial family of enzymes involved in signal transduction.
  • Understanding their structure, regulation, and function is essential for comprehending Ca2+ mediated cellular processes.
  • These kinases represent important targets for further research into cellular signaling and disease.

Related Experiment Videos