Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of two lipid emulsions on platelet function

I Porta1, M Planas, J B Padró

  • 1Santiago Grisolia Metabolic Research Unit, Vall d'Hebron General Teaching Hospital, Barcelona, Spain.

Infusionstherapie Und Transfusionsmedizin
|October 1, 1994
PubMed
Summary

This study found that two different lipid emulsions used in total parenteral nutrition (TPN) did not significantly alter platelet function or eicosanoid production in critically ill patients over a 7-day period.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preferential habitats prediction in syngnathids using species distribution models.

Marine environmental research·2021
Same author

Administration of the probiotic Lactobacillus rhamnosus IMC 501 as a strategy for the control of Vibrio bacteria in the brine shrimp Artemia.

Letters in applied microbiology·2021
Same author

Dynamic expression of Ralstonia solanacearum virulence factors and metabolism-controlling genes during plant infection.

BMC genomics·2021
Same author

Primary, secondary, and tertiary stress responses of juvenile seahorse Hippocampus reidi exposed to acute acid stress in brackish and seawater.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology·2021
Same author

Prevalence and Factors Associated With Fatigue in Patients With Inflammatory Bowel Disease: A Multicentre Study.

Journal of Crohn's & colitis·2019
Same author

Delivering aminopyridine ligands into cancer cells through conjugation to the cell-penetrating peptide BP16.

Organic & biomolecular chemistry·2016

Area of Science:

  • Critical Care Medicine
  • Nutrition Support
  • Hematology

Background:

  • Critically ill patients often require nutritional support via total parenteral nutrition (TPN).
  • The type of lipid emulsion used in TPN can potentially impact various physiological processes, including platelet function.
  • Understanding these effects is crucial for optimizing TPN strategies in intensive care settings.

Purpose of the Study:

  • To investigate the impact of two distinct lipid emulsions on platelet aggregation, activation, and eicosanoid production in nonseptic critically ill patients receiving TPN.
  • To compare the effects of long-chain triglycerides (LCT) versus a combination of medium- and long-chain triglycerides (MCT/LCT) lipid emulsions on platelet parameters.

Main Methods:

  • A prospective, randomized, unblinded study was conducted in an ICU setting.

Related Experiment Videos

  • Twenty-three nonseptic critically ill adult patients requiring at least 7 days of TPN were enrolled.
  • Patients received TPN with either Intralipid 20% (LCT) or Lipofundin MCT/LCT 20%, with platelet function markers assessed at baseline, day 4, and day 7.

    • Main Results:

    • Baseline assessment revealed notable platelet activation and elevated 6-keto-PGF1 alpha levels prior to lipid emulsion administration.
    • No significant changes in platelet aggregation, activation markers (beta-thromboglobulin, platelet factor 4), or 6-keto-PGF1 alpha production were observed at 4 and 7 days of TPN.
    • There were no significant differences in these parameters between the two lipid emulsion groups.

    Conclusions:

    • The administration of either LCT or MCT/LCT lipid emulsions as part of TPN did not adversely affect platelet function in nonseptic critically ill patients during the study period.
    • These findings suggest that both lipid formulations are safe concerning platelet function in this patient population.
    • Further research may explore long-term effects or specific patient subgroups.