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GPI-anchor structure
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Related Experiment Video

Updated: Feb 7, 2026

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Immunotherapy for mountain cedar pollinosis. A double-blind controlled study

H L Pence, D Q Mitchell, R L Greely

    The Journal of Allergy and Clinical Immunology
    |July 1, 1976
    PubMed
    Summary

    Specific injection therapy significantly reduced allergic rhinitis and asthma symptoms caused by mountain cedar pollen. Treated patients showed fewer symptoms and decreased specific IgE antibodies compared to placebo.

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    Area of Science:

    • Allergen immunotherapy
    • Immunology
    • Respiratory medicine

    Background:

    • Allergic rhinitis and asthma are common conditions often triggered by environmental allergens like mountain cedar pollen.
    • Current treatments may not provide sufficient relief for all patients, necessitating evaluation of alternative therapies.

    Purpose of the Study:

    • To evaluate the efficacy of a single preseasonal course of specific injection therapy for mountain cedar allergy.
    • To assess the impact of this therapy on patient symptoms and specific IgE antibody levels.

    Main Methods:

    • A double-blind, placebo-controlled study design was employed.
    • Patients received either specific injection therapy or a placebo before the mountain cedar pollen season.
    • Symptom severity and specific serum IgE antimountain cedar antibody levels were monitored.

    Main Results:

    • Patients receiving specific injection therapy reported significantly fewer allergic rhinitis and asthma symptoms.
    • A decrease in specific serum IgE antimountain cedar antibody was observed in the treated group during the pollen season.
    • An increase in specific serum IgE antimountain cedar antibody was noted in the placebo group.

    Conclusions:

    • A single preseasonal course of specific injection therapy is effective in managing allergic rhinitis and asthma symptoms induced by mountain cedar pollen.
    • The therapy appears to modulate the immune response, as indicated by decreased specific IgE antibody levels.
    • This treatment offers a promising therapeutic option for individuals suffering from mountain cedar allergies.