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Updated: Aug 11, 2026
09:19
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
Published on: February 6, 2015
[The sensitivity of tumor cells to low doses of antitumor preparations]
Izvestiia Akademii Nauk. Seriia Biologicheskaia
|September 1, 1994
Abstract:
The anticancer activity of water solutions of nitrosomethylurea, adriblastin and cisplatin at low and extra low concentrations (to 10(-15) M) was studied in the mice with experimentally induced tumor. Single and multiple administration of these drugs at extra low doses changed the life duration. Nitrosomethylurea (10(-15) M) increased the life duration by 20-86%. Nitrosomethylurea at extra low concentrations modifies the organism and tumor sensitivity to subsequent action of a high dose of this drug.
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