Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The activation antigen CD69

S F Ziegler1, F Ramsdell, M R Alderson

  • 1Department of Molecular Genetics, Immunex Research and Development Corporation, Seattle, Washington 98101.

Stem Cells (Dayton, Ohio)
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IL-33 promotes gastrointestinal allergy in a TSLP-independent manner.

Mucosal immunology·2017
Same author

IL-33 promotes gastrointestinal allergy in a TSLP-independent manner.

Mucosal immunology·2017
Same author

Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response.

Mucosal immunology·2016
Same author

GM-CSF produced by the airway epithelium is required for sensitization to cockroach allergen.

Mucosal immunology·2016
Same author

Thymic stromal lymphopoietin (TSLP)-mediated dermal inflammation aggravates experimental asthma.

Mucosal immunology·2012
Same author

New conjugate vaccines for the prevention of pneumococcal disease in developing countries.

Drugs of today (Barcelona, Spain : 1998)·2011
Same journal

Brent A. Reynolds, pioneer of adult neural stem cell biology.

Stem cells (Dayton, Ohio)·2026
Same journal

CircVapa promotes the abnormal differentiation of small intestinal epithelial stem cells in diabetic state.

Stem cells (Dayton, Ohio)·2026
Same journal

Transforming Growth Factor beta-2 (TGFβ2) Drives Trabecular Meshwork Progenitor Cell Differentiation Through SMAD2/3 Signalling.

Stem cells (Dayton, Ohio)·2026
Same journal

Circular RNA circEGFR overexpression attenuates chemosensitivity and enhances cancer stemness via targeting IGF2BP2/SOX2 in breast cancer cells.

Stem cells (Dayton, Ohio)·2026
Same journal

Regeneration of the mammalian brain: a relic of evolution?

Stem cells (Dayton, Ohio)·2026
Same journal

Mitochondrial transfer technologies with molecular insights into clinical applications.

Stem cells (Dayton, Ohio)·2026
See all related articles

CD69 is an early T cell activation marker that also functions as a costimulatory molecule. Its broad expression across immune cells suggests a key role in regulating immune responses.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • CD69 is an early cell surface antigen expressed on T cells after T cell receptor/CD3 complex ligation.
  • CD69 functions as a costimulatory molecule, enhancing T cell activation and proliferation.
  • CD69 expression is induced in various immune cells, including B cells, NK cells, monocytes, and neutrophils, and constitutively present on mature thymocytes and platelets.

Purpose of the Study:

  • To investigate the role of CD69 as a pleiotropic immune regulator.
  • To understand the structural, chromosomal, and functional characteristics of CD69.
  • To explore CD69's potential importance in NK cell function and hematopoietic cell differentiation.

Main Methods:

  • Isolation of cDNA clones encoding human and mouse CD69.

Related Experiment Videos

  • Gene mapping studies to determine chromosomal localization.
  • Analysis of CD69 expression patterns and functional assays.

    • Main Results:

    • CD69 was identified as a member of the C-type lectin superfamily.
    • Chromosomal localization placed CD69 near the NK gene complex on mouse chromosome 6 and human chromosome 12p13.
    • CD69's structure, localization, and expression suggest a role in immune regulation.

    Conclusions:

    • CD69 is a pleiotropic immune regulator with potential roles beyond NK cells.
    • Its function impacts the activation and differentiation of diverse hematopoietic cells.
    • CD69 is a significant molecule in the broader immune system's regulatory network.