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Related Experiment Videos

Folate-responsive optic neuropathy

K C Golnik1, E R Schaible

  • 1Department of Ophthalmology, Storm Eye Institute Medical University of South Carolina, Charleston 29425.

Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
|September 1, 1994
PubMed
Summary
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Folate deficiency can cause progressive vision loss in optic neuropathy. Supplementing with folic acid improved vision in all patients, highlighting its therapeutic potential.

Area of Science:

  • Ophthalmology
  • Neurology
  • Nutritional Science

Background:

  • Bilateral, progressive visual loss is a concerning symptom.
  • Optic nerve damage can lead to irreversible vision impairment.
  • Certain lifestyle factors and nutritional deficiencies are implicated in optic neuropathies.

Purpose of the Study:

  • To investigate the role of folate deficiency in patients with unexplained bilateral optic neuropathy.
  • To assess the efficacy of folic acid supplementation in treating vision loss associated with this condition.

Main Methods:

  • Examined six patients with bilateral, progressive visual loss.
  • Assessed visual acuity, color vision, visual fields, and optic nerve appearance.
  • Measured folate and vitamin B12 levels.

Related Experiment Videos

  • Treated patients with oral folic acid (1 mg/day).

    • Main Results:

    • All patients had folate deficiency and normal vitamin B12 levels.
    • Tobacco and/or ethanol consumption was common among patients.
    • All patients experienced bilateral improvement in visual acuity (mean: five lines in 2 months) after folic acid treatment.

    Conclusions:

    • Folate deficiency is a potential cause of progressive bilateral optic neuropathy.
    • Folic acid supplementation can significantly improve visual function in affected individuals.
    • Consider folate deficiency in the differential diagnosis of unknown optic neuropathies.