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High blood pressure in older persons: a high risk special population
1Hypertension Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 25157-1032.
Insights
Treating hypertension in older adults is crucial, as high blood pressure (BP) increases cardiovascular disease (CVD) risk. Lowering BP gradually reduces stroke, heart disease, and mortality, even with normal creatinine levels.
Area of Science:
- Gerontology
- Cardiology
- Nephrology
Background:
- Systolic blood pressure (SBP) increases with age, leading to isolated systolic hypertension in individuals over 70.
- Elderly patients face a significantly higher cardiovascular disease (CVD) risk at comparable blood pressure (BP) levels.
- End-organ damage, including renal impairment, is prevalent in elderly hypertensive patients, sometimes with normal serum creatinine.
Purpose of the Study:
- To emphasize the necessity of treating all forms of hypertension (HTN) in the elderly population.
- To review evidence supporting BP reduction in older adults.
- To discuss diagnostic evaluations for secondary HTN and debunk common myths.
Main Methods:
- Meta-analysis of eight clinical trials involving elderly patients.
- Review of existing literature on hypertension management in older adults.
- Analysis of risk factors and end-organ damage in elderly hypertensive patients.
Main Results:
- A 15/6 mm Hg treatment difference was observed between intervention and control groups.
- Intervention groups showed reduced rates of stroke, coronary heart disease (CHD), and all-cause mortality.
- Gradual BP control to normal ranges is recommended without evidence of harm (J-curve hypothesis).
Conclusions:
- All forms of hypertension in the elderly require treatment.
- Therapeutic strategies should consider coexisting medical conditions.
- Effective BP management in older adults significantly lowers CVD risk and mortality.
Abstract:
Blood pressure (BP), particularly systolic blood pressure (SBP), rises with advancing age. Isolated systolic hypertension is the most common type of hypertension (HTN) phenotype after age 70. Moreover, at similar BP levels the absolute risk for CVD is several fold higher in elderly than in young patients. End-organ damage is common, and significant renal impairment can be present even when serum creatinine levels are normal. All forms of HTN in the elderly should be treated. A recent meta-analysis of eight clinical trials involving elderly patients documented a 15/6 mm Hg treatment difference between intervention and control groups, and a lower rate of stroke, CHD and death from all causes in the intervention group. Gradual BP control into the "normal" range should be the goal in elderly patients. There is no convincing evidence that lowering BP is harmful (J-curve hypothesis). Coexisting medical conditions influence therapeutic choices. The suggested medical evaluation of elderly hypertensive patients with suspected secondary forms of HTN is covered as well as pervasive clinical myths about HTN in the elderly.
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