[Initial experience with therapy of endogenous uveitis with Consupren--the Czech cyclosporin A]

The authors treated as part of a controlled trial, five patients with Consupren, Galen a Co, i.e. the Czech preparation of cyclosporin A. All patients suffered from endogenous uveitis which was refractory to treatment with a combination of prednisone and cyclophosphamide or prednisone and azathioprin. Mitigation of the disease was achieved already during the first three weeks of treatment. In two patients during treatment a slight relapse of the inflammation was observed. As to side effects of this treatment, the authors observed only once readily controllable hypertension and a rise of some indicators of liver metabolism which returned to normal already during treatment. Side-effect in conjunction with renal affection were not observed in any of the patients. Based on these preliminary results the authors assume that Consupren is in the given indication, and when the described pattern of administration is used, effective and justifies the authors to continue with their investigation.