Ionizing radiation-induced IL-1 alpha, IL-6 and GM-CSF production by human lung cancer cells

¹MPH Radiobiology Research Unit, Norman Bethune University of Medical Sciences, Changchun.

|September 1, 1994

Abstract:

A cell line derived from human lung cancer (AOI) was employed in the present study. A panel of cytokines were quantified by ELISA technique following cellular exposure to X-irradiation. Tremendous increase in the levels of both IL-1 alpha and IL-6 were observed, GM-CSF was also detected. A comparison of time kinetics of IL-1 alpha and IL-6 production was made with that of cell cycle progression which was determined by FCM BrdU/DNA bivariate analysis. No cell cycle specific changes were found. The biological implication of radiation-induced cytokine production was discussed.

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