[Protective effect of interleukin-1 receptor antagonist on oleic acid-induced lung injury]

Thirty-six mice were divided into a control group, lung injury group by oleic acid and protected group with interleukin-1 receptor antagonist (IL-1ra). There were 12 mice in each group. Oleic acid was injected into the tail vein of the mouse with a dose of 0.2 ml/kg to produce a model of acute lung injury (ALI). The result indicates that preadministration of IL-1ra to the mouse with ALI can decrease the lung index, lung wet-to-dry weight ratio and leakage of protein from pulmonary capillary, elevate PaO2, and significantly attenuate lung histologic injury (alveoli edema, alveoli hemorrhage, lung necrosis, inflammatory cell invasion). It is suggested that IL-1ra has protective effect on oleic acid-induced lung injury and may be a potential tool for treatment of ARDS.