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Cushing's syndrome and pregnancy
1Department of Endocrinology, Innova Medical Services, Cleveland, Ohio.
Endocrinology and Metabolism Clinics of North America
|September 1, 1994
Summary
Pregnancy is rare for women with active Cushing's syndrome, often leading to complications. Treatment options like surgery or radiation may be considered for affected individuals.
Area of Science:
- Endocrinology
- Reproductive Medicine
- Oncology
Background:
- Cushing's syndrome is a rare endocrine disorder caused by prolonged exposure to high cortisol levels.
- Active Cushing's syndrome significantly impacts reproductive health in women, leading to infertility.
- Limited data exists on pregnancy outcomes and therapeutic interventions in this population.
Observation:
- Only 69 pregnancies in women with active Cushing's syndrome have been documented.
- A high incidence of maternal and fetal complications (60 out of 69) was observed.
- Therapeutic interventions included unilateral adrenalectomy, bilateral adrenalectomy, pituitary surgery, and pituitary radiation.
Findings:
- Women with active Cushing's syndrome face a high risk of pregnancy complications.
- Surgical and radiological treatments have been employed in managing Cushing's syndrome during pregnancy.
- Successful conception and delivery in the context of Cushing's syndrome are infrequent and high-risk.
Implications:
- Early diagnosis and management of Cushing's syndrome are crucial for improving reproductive outcomes.
- Further research is needed to optimize treatment strategies for pregnant women with Cushing's syndrome.
- This underscores the importance of multidisciplinary care for managing endocrine disorders during pregnancy.