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Immunization of cattle with recombinant Babesia bovis merozoite surface antigen-1
S A Hines1, G H Palmer, D P Jasmer
1Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
Infection and Immunity
|January 1, 1995
Abstract:
Cattle immunized with a recombinant merozoite surface antigen-1 molecule (MSA-1) produced high-titered antibody that reacted with the surface of the parasite and neutralized merozoite infectivity in vitro. However, recombinant MSA-1 immunization did not confer protection against challenge with virulent Babesia bovis. These results indicate that antibody-mediated neutralization of merozoite infectivity in vitro, at least for MSA-1-specific antibody, does not reflect in vivo protective immunity to babesiosis.