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Excitotoxicity and cholinergic chemical markers during programmed motor neurone death
D Rodríguez-Ithurralde1, O Vincent
1Division of Neuromyology, Instituto de Investigaciones Biológicas Clemente Estable (IIBCE), Montevideo, Uruguay.
Journal of the Neurological Sciences
|July 1, 1994
Abstract:
We measured cholinergic markers and acetylcholinesterase (AChE) molecular forms after glutamate receptor stimulation of superfused slices of mouse spinal cord at different developmental ages. AChE globular forms were secreted in a dose-dependent fashion. A period of selective sensitivity to excitotoxic agents was detected by increased acetylcholine (ACh) release and AChE secretion (sAChE) at postnatal day 14. Strychnine-resistant glycine stimulation potentiated glutamate-induced AChE release, suggesting N-methyl-D-aspartate (NMDA) receptor involvement.