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Distinct MLL gene rearrangements associated with successive acute monocytic and lymphoblastic leukemias in the same
P Jonveaux1, J Hillion, O Bernard
1Unité INSERM U301, Institut de Génétique Moléculaire, Paris, France.
Leukemia
|December 1, 1994
Abstract:
A patient with acute monocytic leukemia (AMoL) and t(6;11)(q27;q23) developed acute lymphoblastic leukemia (ALL) and t(4;11)(q21;23), 10 months after complete remission of the AMoL. The MLL gene, normally located at band 11q23, appeared differently rearranged in the cells of these two leukemias, showing a different origin for the two malignant clones. The responsibility of etoposide, used in treatment of the AML, in the occurrence of the ALL is probable in this patient.