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Detection and characterization of eukaryotic enzymes that recognize oxidative DNA damage

K K Hamilton1, K Lee, P W Doetsch

  • 1Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322.

Methods in Enzymology
|January 1, 1994
PubMed
Abstract

No abstract available in PubMed .

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Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...