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Related Experiment Videos

Neonatal typhoid fever

R P Reed1, K P Klugman

  • 1Shongwe Hospital, Shongwe Mission, Johannesburg, South Africa.

The Pediatric Infectious Disease Journal
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

Neonatal typhoid fever, caused by Salmonella typhi, is a severe illness in infants. Early recognition and appropriate antibiotic therapy are crucial for survival, especially in endemic regions.

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Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Neonatology

Background:

  • Typhoid fever is often mild in young children but can be severe in neonates.
  • Neonatal typhoid fever, historically fatal, can result from intrauterine transmission.
  • Infants can also acquire severe infections exogenously.

Purpose of the Study:

  • To describe the clinical presentation and outcomes of neonatal typhoid fever.
  • To highlight the importance of considering Salmonella typhi in neonatal sepsis.
  • To evaluate empiric management strategies.

Main Methods:

  • Retrospective case series of ten infants with typhoid fever.
  • Analysis of clinical data, treatment, and outcomes.
  • Review of management appropriateness.

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Main Results:

  • Three of ten neonates died, with two deaths linked to inappropriate empiric antibiotic management.
  • Identified two clinical presentations: severe illness and asymptomatic excretion.
  • Highlighted risk of severe disease from exogenous sources in infants under 3 weeks.

Conclusions:

  • Salmonella typhi should be considered in neonatal sepsis cases in typhoid-endemic areas.
  • Empiric antibiotic regimens for neonatal sepsis must include agents effective against S. typhi.
  • Timely and appropriate treatment is vital for improving outcomes in neonatal typhoid fever.