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Childhood sarcoidosis presenting with hypercalcaemic crisis
A L Hoffmann1, N Milman, H E Nielsen
1Department of Pediatrics, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Sarcoidosis
|September 1, 1994
Summary
This study details a rare case of hypercalcaemic crisis in a teenage boy caused by sarcoidosis. Treatment with steroids effectively normalized calcium levels and improved his condition.
Area of Science:
- Pediatric Endocrinology
- Pulmonology
- Rheumatology
Background:
- Sarcoidosis is an inflammatory disease that can affect multiple organs.
- Hypercalcemia is a potential complication of sarcoidosis, though less common in children.
- Early diagnosis and management are crucial for favorable outcomes.
Observation:
- A 15-year-old male presented with a hypercalcemic crisis.
- Clinical suspicion of sarcoidosis was confirmed via liver biopsy.
- Elevated serum calcium, 1,25(OH)2 vitamin D, and Angiotensin-Converting Enzyme (ACE) with suppressed intact Parathyroid Hormone (iPTH) were noted.
Findings:
- Systemic steroid treatment led to clinical improvement.
- Biochemical markers including serum calcium, iPTH, ACE, 1,25(OH)2, and 25-OH vitamin D normalized within five weeks.
- Chest X-ray and pulmonary function tests were monitored throughout treatment.
Implications:
- This case clarifies the mechanism of hypercalcemia in childhood sarcoidosis.
- Highlights the importance of considering sarcoidosis in pediatric hypercalcemia.
- Demonstrates the efficacy of steroid therapy in managing this condition in adolescents.