Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in blood coagulation during total hip replacement

G R Houghton, E G Papadakis, C R Rizza

    Lancet (London, England)
    |June 24, 1978
    PubMed
    Summary

    Clotting factors II, V, and VIII were significantly higher in the operated leg during hip replacement surgery. Reducing blood pooling in the operated leg may help prevent deep-vein thrombosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The first patient to receive factor IX concentrate in the UK: a recollection.

    Haemophilia : the official journal of the World Federation of Hemophilia·2016
    Same author

    A method for identification of vertebral level.

    Annals of the Royal College of Surgeons of England·2009
    Same author

    Treatment of haemophilia in the United Kingdom 1981-1996.

    Haemophilia : the official journal of the World Federation of Hemophilia·2001
    Same author

    Mortality from liver cancer and liver disease in haemophilic men and boys in UK given blood products contaminated with hepatitis C. UK Haemophilia Centre Directors' Organisation.

    Lancet (London, England)·1997
    Same author

    Importance of age at infection with HIV-1 for survival and development of AIDS in UK haemophilia population. UK Haemophilia Centre Directors' Organisation.

    Lancet (London, England)·1996
    Same author

    Mortality before and after HIV infection in the complete UK population of haemophiliacs. UK Haemophilia Centre Directors' Organisation.

    Nature·1995

    Area of Science:

    • Orthopedic Surgery
    • Hematology
    • Vascular Medicine

    Background:

    • Osteoarthritis of the hip is a common condition requiring surgical intervention.
    • Total hip replacement is a major orthopedic procedure associated with risks such as deep-vein thrombosis (DVT).
    • Understanding the localized hemostatic changes during surgery is crucial for DVT prevention strategies.

    Purpose of the Study:

    • To investigate the concentrations of specific clotting factors in the operated limb compared to the systemic circulation during total hip replacement.
    • To determine if localized increases in clotting factors correlate with the risk of DVT.

    Main Methods:

    • Blood samples were collected from seventeen patients undergoing total hip replacement.
    • Clotting factors II, V, and VIII were measured in blood from the operated limb and the general systemic circulation.
    • Statistical analysis was performed to compare factor concentrations between the two sites.

    Main Results:

    • Concentrations of clotting factors II, V, and VIII were consistently and significantly higher in the operated limb.
    • This localized elevation suggests increased clotting potential within the surgical site's vasculature.
    • The findings indicate a potential mechanism contributing to thrombus formation in the operated limb.

    Conclusions:

    • Elevated clotting factor levels in the operated limb during hip replacement surgery may contribute to DVT risk.
    • Implementing measures to reduce venostasis (blood pooling) in the operated leg could be a viable strategy for DVT prevention.
    • Further research into localized hemostatic modulation during orthopedic procedures is warranted.

    Related Experiment Videos