Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoimmune diseases as stem cell disorders

S Ikehara1, M Inaba, R Yasumizu

  • 1First Department of Pathology, Kansai Medical University, Osaka, Japan.

The Tohoku Journal of Experimental Medicine
|May 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stagnation in the decline of TB in Japan: introduction of the pre-entry TB screening programme.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2025
Same author

Ensuring continuous TB treatment across Asian borders.

Public health action·2024
Same author

Formation and evolution of carbonaceous asteroid Ryugu: Direct evidence from returned samples.

Science (New York, N.Y.)·2022
Same author

Cutaneous ischemia-reperfusion injury is exacerbated by IL-36 receptor antagonist deficiency.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

A patient with bullous pemphigoid with mucosal involvement serologically positive for anti-BP230 autoantibodies only.

The British journal of dermatology·2019
Same author

Herbicide-resistant transgenic creeping bentgrass plants obtained by electroporation using an altered buffer.

Plant cell reports·2019

Bone marrow transplantation (BMT) prevents and treats autoimmune diseases, including diabetes and nephritis, by addressing stem cell defects. Combining BMT with bone grafts offers a promising strategy for autoimmune disease treatment.

Area of Science:

  • Immunology
  • Transplantation Medicine
  • Autoimmune Diseases

Background:

  • Autoimmune diseases, including insulin-dependent diabetes mellitus (IDDM), arise from complex genetic and environmental factors.
  • Current treatments for autoimmune diseases often manage symptoms rather than addressing the underlying pathology.
  • Bone marrow transplantation (BMT) has shown potential in treating certain autoimmune conditions, but relapse can occur.

Purpose of the Study:

  • To investigate the efficacy of allogeneic bone marrow transplantation (BMT) in preventing and treating autoimmune diseases using animal models.
  • To explore the role of hematopoietic stem cells (HSCs) and stromal cells in the pathogenesis and treatment of autoimmune diseases.
  • To evaluate BMT with bone grafts as a therapeutic strategy for both organ-specific and systemic autoimmune diseases.

Related Experiment Videos

Main Methods:

  • Utilized NOD mice for IDDM studies and (NZB x NZW) F1, BXSB, (NZW x BXSB) F1, and MRL/lpr mice for systemic autoimmune disease models.
  • Performed allogeneic bone marrow transplantation (BMT), combined pancreas and BMT, and BMT with bone grafts.
  • Transferred HSCs from autoimmune-prone mice to normal mice to establish chimeric models and assess disease induction.

Main Results:

  • Allogeneic BMT prevented IDDM in NOD mice and treated systemic autoimmune diseases in several mouse strains, with relapse in MRL/lpr mice attributed to abnormal HSCs.
  • Transplantation of HSCs with bone to recruit stromal cells demonstrated a curative effect on autoimmune diseases in MRL/lpr mice.
  • Transferring HSCs from autoimmune-prone mice induced organ-specific and/or systemic autoimmune diseases in recipient mice, confirming HSC defects as the cause.
  • BMT showed potential for treating non-insulin-dependent diabetes mellitus and chronic nephritis, suggesting they are organ-specific autoimmune diseases.

Conclusions:

  • Defects in hematopoietic stem cells (HSCs) are the primary cause of both organ-specific and systemic autoimmune diseases.
  • Bone marrow transplantation, particularly with bone grafts to support HSCs, is a promising therapeutic strategy for various intractable autoimmune diseases.
  • This research provides direct evidence for the etiopathogenesis of autoimmune diseases and supports BMT as a valuable treatment approach.