[Long-term administration of biphosphonates in oncology patients with bone involvement]

The usefulness of bisphosphonates in the treatment of acute hypercalcaemia has been known for some time. The problem of long-term administration of bisphosphonates to patients whose skeleton is afflicted with a malignant tumour is still being discussed. The benefit of ethidronate has not been confirmed. Clodronate and pamidronate administered in i.v. infusions or in adequate amounts by the oral route leads to a reduced incidence of hypercalcaemic crises and the number of pathological fractures. Both mentioned preparations diminish the intensity of pain, increase physical fitness and improve the quality of life of oncological patients. However, they do not prolong the survival period of these patients.