Related Experiment Video
Updated: Oct 17, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
[The etiopathogenetic significance of vitamin D3 in osteoarthropathia psoriatica]
Abstract:
1.25 (OH)2 D3 is the most effective natural metabolite of vitamin D. By binding to a specific receptor (VDR) it develops genomic as well as non genomic effects which exceed the effects on calcium regulation. Exercising an influence on immunological phenomena and on the behavior of cellular differentiation and proliferation, the different manifestations of psoriatic osteoarthropathy (skin lesions, chronic synovialitis, increased bone remodeling) may be due to a common pathogenetic process of a disturbed vitamin D metabolism. However, the supposed fault has not yet been defined and this concept is still hypothetical. Moreover, it is probable that it represents a partial aspect only in the quite unclear pathogenesis of the disease.
Related Concept Videos
Connective Tissue Cell Types
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
The JAK-STAT Signaling Pathway
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

