Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Force-frequency relations during heart failure in pigs

G P Eising1, H K Hammond, G A Helmer

  • 1Department of Medicine, University of California, San Diego, La Jolla 92093-0613.

The American Journal of Physiology
|December 11, 1994
PubMed
Summary

In severe heart failure (HF), the basal force-frequency relation (FFR) in the intact heart is not negative. Beta-adrenergic stimulation does not enhance FFR in HF, unlike in healthy hearts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnosis and hybrid interventional and surgical removal of ectopic heartworms (Dirofilaria immitis) in a dog.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2024
Same author

Transvenous occlusion of patent ductus arteriosus in a domestic chicken (Gallus gallus).

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2021
Same author

Simultaneous administration of G-CSF and GM-CSF for re-mobilization in patients with inadequate initial progenitor cell collections for autologous transplantation.

Cytotherapy·2002
Same author

Capillary leak syndrome after cardiopulmonary bypass in elective, uncomplicated coronary artery bypass grafting operations: does it exist?

The Journal of thoracic and cardiovascular surgery·2002
Same author

Effect of C1-esterase-inhibitor on capillary leak and inflammatory response syndrome during arterial switch operations in neonates.

Journal of cardiothoracic and vascular anesthesia·2001
Same author

Does a hyperoncotic cardiopulmonary bypass prime affect extravascular lung water and cardiopulmonary function in patients undergoing coronary artery bypass surgery?

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2001

Area of Science:

  • Cardiology
  • Physiology
  • Heart Failure Research

Background:

  • The force-frequency relation (FFR) describes how heart muscle contractility changes with heart rate.
  • In isolated cardiac muscle from severe heart failure (HF) patients, FFR is often negative.
  • FFR characteristics in the intact, failing heart and its response to adrenergic stimulation remain understudied.

Purpose of the Study:

  • To investigate the basal FFR in an intact, failing heart model.
  • To determine the effect of adrenergic stimulation on FFR in severe HF.
  • To compare FFR in healthy vs. failing hearts under varying conditions.

Main Methods:

  • Severe HF was induced in pigs via rapid ventricular pacing.
  • Left ventricular (LV) pressure and dP/dtmax were measured at various atrial pacing rates before and after HF induction.

Related Experiment Videos

  • The impact of dobutamine (adrenergic stimulant) and a sinus node inhibitor on FFR was assessed.

    • Main Results:

    • Before HF, the FFR was flat, but dobutamine induced a positive slope.
    • After HF, basal FFR was depressed, and dobutamine did not increase its slope.
    • Responses to heart rate reduction confirmed the absence of a negative basal FFR in HF.

    Conclusions:

    • The basal LV FFR in conscious pigs with severe HF is not negative.
    • Unlike in normal hearts, beta-adrenergic stimulation does not amplify FFR in HF.
    • This blunted FFR response to adrenergic stimulation may contribute to impaired exercise capacity in HF patients.