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Extrahepatic immunologic manifestations in chronic hepatitis C and hepatitis C virus serotypes

J M Pawlotsky1, F Roudot-Thoraval, P Simmonds

  • 1Université de Paris XII, Créteil, France.

Annals of Internal Medicine
|February 1, 1995
PubMed

Insights

Extrahepatic immunologic disorders are common in chronic hepatitis C patients, regardless of hepatitis C virus (HCV) serotype. This study found no significant difference in the prevalence of these conditions across different HCV serotypes.

Area of Science:

  • Hepatology
  • Immunology
  • Virology

Background:

  • Chronic hepatitis C (HCV) infection is associated with a high prevalence of extrahepatic immunologic abnormalities.
  • The role of specific HCV serotypes in the development of these disorders remains unclear.

Purpose of the Study:

  • To investigate whether extrahepatic immunologic disorders in patients with chronic hepatitis C are dependent on the hepatitis C virus serotype.
  • To determine the prevalence of specific immunologic abnormalities in relation to HCV serotype.

Main Methods:

  • A prospective study involving 59 consecutive patients with chronic hepatitis C.
  • HCV serotyping was performed using an immunoenzymatic assay.
  • Assessment included cryoglobulin, rheumatoid factor, antitissue antibodies, and salivary gland biopsies.

Main Results:

  • HCV serotype 1 was most prevalent (59%), followed by serotype 3 (12%) and serotype 2 (10%).
  • Cryoglobulinemia (36%), rheumatoid factor (71%), and antitissue antibodies (41%) were common.
  • Lymphocytic capillaritis was observed in 49% of salivary gland biopsies.
  • The prevalence of these immunologic abnormalities did not significantly differ among patients infected with different HCV serotypes.

Conclusions:

  • Extrahepatic immunologic abnormalities are highly prevalent in patients with chronic hepatitis C.
  • These abnormalities can occur irrespective of the hepatitis C virus serotype, suggesting a common pathogenic mechanism across serotypes.
Abstract

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