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7-OHDPAT and alcohol consumption, withdrawal and discriminative stimulus properties in rats
1Department of Neuropsychopharmacology, Janssen Research Foundation, Beerse, Belgium.
Alcohol and Alcoholism (Oxford, Oxfordshire)
|September 1, 1994
Abstract:
A series of experiments was performed, which indicated that 7-OHDPAT is only active in rats that are still in the dynamic phase of the development of a high and stable level of alcohol preference and in a drug discrimination test procedure, but not in rats with a matured preference for 3% alcohol. These data may point to a limited use of 7-OHDPAT in conditions of alcohol misuse and dependence.