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5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment
R Perrone1, F Berardi, M Leopoldo
1Dipartimento Farmaco-Chimico, Bari, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|September 1, 1994
Abstract:
The synthesis of some arylpiperazines with a benzamide moiety on N-4 alkyl chain was accomplished and their dopaminergic and serotonergic affinity was assayed by in vitro receptor binding. The results of such investigation showed a moderate affinity on D-2 receptors and a lack of 5-HT receptor affinity.