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The presence of tumour necrosis factor in CSF and plasma after severe head injury
S A Ross1, M I Halliday, G C Campbell
1Queen's University of Belfast, Department of Surgery, Northern Ireland.
British Journal of Neurosurgery
|January 1, 1994
Abstract:
In a cohort of victims of traumatic brain injury, 18 out of 50 patients had a plasma tumour necrosis factor (TNF) concentration above 2 pg/ml within 24 h of injury (mean 12.19, SD 45.96 pg/ml). Twenty-six had CSF samples available of which 17 demonstrated TNF concentrations above 1 pg/ml (mean 3.98, SD 3.61 pg/ml). We conclude that traumatized brain parenchyma is a significant source of TNF activity and implicate the cytokine in cellular metabolic derangements following head injury.