[Hemifacial malignant granuloma as clinical manifestation of peripheral T-cell lymphoma]

The present clinical and pathological study describes the cases of two patients having infiltrate and ulcerous lesions of the nose, hard palate and rhinopharynx clinically consistent with a malignant midline granuloma. Histologically, infiltrates presented atypical lymphoid cells around small vessels and damage of the vascular wall. Immunohistologic study, using monoclonal antibodies on both fresh and paraffin embedded tissues, led to the positive diagnosis of peripheral lymphoma of T cells.