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Related Experiment Videos

An estimated shape function for drift in a platelet-transport model

C Yeh1, A C Calvez, E C Eckstein

  • 1Department of Biomedical Engineering, University of Miami, Coral Gables, Florida 33124.

Biophysical Journal
|September 1, 1994
PubMed
Summary
This summary is machine-generated.

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Near-wall excesses in flowing blood are modeled using a drift shape function. Experiments with platelet-sized beads confirm this function

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Hematology

Background:

  • Platelet concentration profiles in blood flow can exhibit near-wall excesses.
  • Existing models use convective diffusion equations, but lack mechanisms for shear-induced redistribution.

Purpose of the Study:

  • To experimentally determine the shape function for a model describing near-wall platelet excess.
  • To validate a model incorporating shear flow effects on particle distribution.

Main Methods:

  • Experiments used platelet-sized latex beads in a 40% hematocrit blood suspension.
  • Flow conditions included a 217-micron tube inner diameter and a 555 s-1 wall shear rate.
  • Average concentration profiles were measured to calculate the drift shape function.

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Main Results:

  • An average concentration profile was obtained under specific experimental conditions.
  • The shape function for the redistribution model was calculated from the experimental data.
  • Similar shape function estimates were found for 15% hematocrit, suggesting broader applicability.

Conclusions:

  • The study provides an experimentally derived shape function for modeling near-wall particle excesses in blood flow.
  • The findings support the use of drift functions to account for shear-induced redistribution in blood flow models.
  • The model and shape function show potential for describing platelet behavior in microcirculation.