Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cortical circuitry in a dish

¹INSERM U.371, Bron, France.

Current Opinion in Neurobiology

|August 1, 1994

Summary

This summary is machine-generated.

The mammalian neocortex organizes connections into layers. Organotypic co-cultures mimic in vivo development, revealing cellular strategies for layer-specific cortical connections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Bacterial colonization of microbial biofilms in oral squamous cell carcinoma.

Clinical oral investigations·2013

Same author

Neurogenesis in the adult dentate gyrus after cortical infarcts: effects of infarct location, N-methyl-D-aspartate receptor blockade and anti-inflammatory treatment.

Neuroscience·2005

Same author

Semaphorin 3A-vascular endothelial growth factor-165 balance mediates migration and apoptosis of neural progenitor cells by the recruitment of shared receptor.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2001

Same author

Axonal surface molecules act in combination with semaphorin 3a during the establishment of corticothalamic projections.

Cerebral cortex (New York, N.Y. : 1991)·2001

Same author

The polysialic acid moiety of the neural cell adhesion molecule is involved in intraretinal guidance of retinal ganglion cell axons.

Developmental biology·2001

Same author

Spatial distributions of guidance molecules regulate chemorepulsion and chemoattraction of growth cones.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2000

Same journal

Cichlid fish as a model for understanding social dysfunction.

Current opinion in neurobiology·2026

Same journal

On aims and methods in field neuroethology: Investigating neural mechanisms of behavior in semi-natural and natural contexts.

Current opinion in neurobiology·2026

Same journal

Neurobiological interfaces connecting environmental change to monarch butterfly migration.

Current opinion in neurobiology·2026

Same journal

Learning how to experience the world: From circuits to cell types to genes.

Current opinion in neurobiology·2026

Same journal

Optical voltage imaging: ready to spark systems neuroscience.

Current opinion in neurobiology·2026

Same journal

The neuroendocrine basis for parental care in teleost fish.

Current opinion in neurobiology·2026

See all related articles

Area of Science:

Neuroscience
Developmental Biology
Cellular Biology

Background:

The mammalian neocortex exhibits layered organization for local and long-range connections.
Understanding how these layer-specific connections form is crucial for brain development.

Purpose of the Study:

To investigate the cellular mechanisms underlying the development of layer-specific cortical connections.
To compare connection patterns in organotypic co-cultures with in vivo observations.

Main Methods:

Utilized organotypic co-culture models of the mammalian neocortex.
Analyzed patterns of afferent and efferent cortical connections within these cultures.

Main Results:

Observed that connection patterns in co-cultures closely resemble those found in vivo.

Related Experiment Videos

Demonstrated the formation of layer-specific cortical connections in vitro.

Conclusions:

Organotypic co-cultures serve as a valid model for studying cortical development.
Identified key cellular strategies involved in establishing layer-specific cortical circuitry.