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Updated: Aug 13, 2026

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging
Published on: December 12, 2012
Linearity of synaptic interactions in the assembly of receptive fields in cat visual cortex
1Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208.
Abstract:
Recent extra- and intracellular recordings from simple cells in the striate cortex have led to the development of detailed models of how novel receptive field properties are generated by the neuronal circuitry of the cortex. The first stage in assembling simple receptive fields appears to be a linear combination of visual inputs. The output of the linear stage is then normalized by a contrast gain control mechanism. Finally, a threshold and expansive nonlinearity in the spike-generating mechanism enhances selectivity for stimulus features such as orientation, direction, and spatial frequency.
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