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Autoreactive T cell-dependent polyclonal hypergammaglobulinemia in mantle cell lymphoma
M Hirokawa1, M Lee, A Kitabayashi
1Department of Internal Medicine, Akita University School of Medicine, Japan.
Leukemia & Lymphoma
|August 1, 1994
Abstract:
We investigated the mechanism of polyclonal B cell differentiation in mantle cell lymphoma (MCL) using peripheral blood mononuclear cells (PBMC) from a patient with MCL in leukemic stage presenting polyclonal hypergammaglobulinemia. Patient T cells not only responded to autologous non-T cells but induced polyclonal production of IgG in vitro. Flow cytometric analysis of PBMC showed the increased conversion of CD4+ T cells from the naive to the memory state. We propose the possible mechanism that autoreactive T cells may be involved in polyclonal B cell differentiation in this monoclonal B cell disorder.