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Corticosteroids and peptic ulceration

J E Ellershaw1, M J Kelly

  • 1St Christopher's Hospice, Sydenham, London, UK.

Palliative Medicine
|October 1, 1994
PubMed
Summary
This summary is machine-generated.

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Corticosteroids increase peptic ulcer risk, especially with higher doses or NSAID use. Prophylaxis is recommended for patients with multiple risk factors like prior ulcers or advanced cancer.

Area of Science:

  • Gastroenterology and Pharmacology

Background:

  • Corticosteroids are widely used but linked to peptic ulceration.
  • Gastrointestinal complications like hemorrhage and perforation are significant concerns.

Purpose of the Study:

  • To review the literature on corticosteroids and peptic ulceration.
  • To identify risk factors for peptic ulceration in patients on corticosteroids.
  • To discuss prophylaxis strategies for at-risk patients.

Main Methods:

  • Literature review of studies on corticosteroids and peptic ulcer disease.
  • Analysis of identified risk factors for peptic ulceration.
  • Evaluation of prophylactic measures.

Main Results:

  • Increased corticosteroid dose, prior peptic ulcer history, advanced malignancy, and concurrent NSAID use are key risk factors.

Related Experiment Videos

  • Patients with two or more risk factors have a higher incidence of peptic ulceration.

    • Conclusions:

    • Prophylaxis against peptic ulceration should be considered for high-risk patients.
    • The choice and efficacy of prophylactic treatments warrant further consideration.