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Swelling-induced K+ influx in cultured primary astrocytes
A A Mongin1, S L Aksentsev, S N Orlov
1Institute of Photobiology, Belarus Academy of Sciences, Minsk, Belarus.
Brain Research
|August 29, 1994
Abstract:
The effect of swelling of cultured primary astrocytes from rat brain in hypotonic medium on K+ influx has been studied. A decrease in osmolality from 310 to 180 mOsm increased the activity of sodium pump (ouabain-inhibited 86Rb+ influx) and Na+,K+,2Cl- cotransport (ouabain-insensitive bumetanide-inhibited 86Rb+ influx) by 70 and 35%, respectively. It is suggested that activation of these transport systems makes it possible to retain a high potassium concentration in the cells under regulatory volume decrease.